Preheat oven to 375°F.
Heat a large skillet over medium heat. Add ground beef and sliced mushrooms. Cook for 6 to 8 minutes, breaking apart the beef as it cooks, until browned and mushrooms are softened. Drain excess grease if needed.
Stir in garlic powder, onion powder, thyme, salt, pepper, Worcestershire sauce, and Dijon mustard. Cook for 1 additional minute.
Blend cottage cheese and beef broth together until completely smooth with no visible texture.
Add uncooked egg noodles to a 9x13 baking dish. Pour in the cottage cheese and broth mixture, then add the beef and mushroom mixture. Stir well until evenly combined and noodles are mostly covered in liquid.
Cover tightly with foil, crimping the edges firmly. Bake for 35 to 40 minutes until noodles are tender. Stir once halfway through if desired.
Remove from oven and let cool for 2 to 3 minutes. Stir in Greek yogurt until fully combined and creamy.
Let sit for 5 to 10 minutes before serving to allow the sauce to thicken. Top with chopped parsley and extra black pepper.